Tuesday, April 12, 2005

Eclectic

..."but sir, that's a graveyard!" (Meaningless quote.)

...shards
Shards of ice in my
Soul... O vainglorious
Reddened angel of
Tybalt, I feel--
As Empedocles did--
Collapsing in the assembly--
Choking on flower petals--
Which were shards--
In my soul (Terrible poem.)

...growth factors can promote progress through the cell cycle; these growth factors are called mitogens; e.g. EGF and FGF2. Most mitogens act during G1-phase; they trigger signalling pathways that release brakes on Cdk. For example, EGF binds to EGF receptor (an RTK); this activates a Ras-MAP kinase signalling cascade which activates Myc. Myc is itself a gene activator protein and its effects ultimately result in increased E2F activity. Myc activates the cyclin D gene which activates G1-Cdk which leads to Rb phosphorylation; Myc also activates the gene for SCF which increases p27 degradation which activates G1/S-Cdk which leads to increased Rb phosphorylation. Myc also activates transcription of the E2F gene itself. So increased Rb phosphorylation and increased E2F transcription and translation lead to increased E2F activity which drives the cell into S-phase. (A paragraph I have to know the hell out of.)

RACHEL: We need a new icebox.
THOM: I'll do it tommorow.
RACHEL: Get up off the couch and get to the store.
THOM: Ring road Supermarket: on Sundays.
RACHEL: It is Sunday!
(NOAH Throws a ping-pong ball at the news anchor on TV.)
THOM: BUt I have a new track to mix tonight.
RACHEL: What does that have to do with anything? (An imagining of Thom Yorke's domestic life.)

Consider: "your response to this."

1 Comments:

Blogger Y said...

THOM:
I don't know why you bother
Nothing's ever good enough
for you
[...]
You came here
Just to start a fight


:D

10:09 PM  

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